Glucosamine Sulfate

Glucosamine is a natural amino sugar found in our body tissues that cushion our joints. The body produces glucosamine naturally and distributes it in cartilage and other connective tissue. It plays a key role in cartilage construction and the incorporation of sulfur into cartilage. Glucosamine sulfate potassium has been studied for its role in joint stiffness, joint swelling, and everyday comfort in people with osteoarthritis. Researchers have also looked at how it relates to changes in knee-joint space over time. Your body’s natural glucosamine levels decrease as you age. This can lead to a slow breakdown of the joint compounds. This therefore weakens your joints and can leave them feeling sore. This is why glucosamine is such a popular supplement and ingredient for supporting everyday joint comfort. It is sold as a dietary supplement for joint support, and the Food and Drug Administration (FDA) regulates it as a food rather than a drug. People spend nearly 21 billion dollars annually on natural joint supplements. We would like to explain further why Flexcin includes glucosamine sulfate potassium as a key ingredient in our joint supplement.

Clinical Studies of Glucosamine

A recent National Institutes of Health (NIH) published study regarding glucosamine analyzed 54 different clinical studies involving 16,427 knee osteoarthritis (OA) patients. The aim was to look at how glucosamine performed for pain and joint function across those studies. This study analyzed and gathered the results from other clinical studies to investigate glucosamine, chondroitin, the two in combination, or celecoxib in people with OA. They took a careful look at each study to determine if the results were reliable, they looked at adverse reactions, and published their results. A meta-analysis indexed by the National Institutes of Health looked at glucosamine sulfate and reported differences versus placebo in participants' self-reported joint comfort and function. Research on glucosamine remains mixed, and results vary between studies and individuals. The same analysis also reported that the five treatment options it reviewed did not differ significantly from one another with respect to adverse effects, though a separate classical meta-analysis found a higher rate of gastrointestinal adverse effects with celecoxib than with placebo.

What About Chondroitin?

Glucosamine is often found paired with chondroitin in supplements. Chondroitin is a complex carbohydrate that the body produces naturally to help cartilage retain water and cushion the joints. Studies on chondroitin have been mixed and do not confirm a consistent effect on discomfort when it is taken orally. The reasons for inconsistent results in studies that use chondroitin are uncertain. It may be caused by differences in products, study design, or study subjects. In general, studies suggest that people with osteoarthritis may gain some advantage from taking chondroitin, but the effect on comfort is likely to be smaller. For more information on chondroitin, we wrote an in depth article that can be found here.

Glucosamine Types

When it comes to glucosamine there are different types. The two types that most commonly used in supplements are glucosamine sulfate potassium or GSP, which is the glucosamine used in Flexcin, and glucosamine hydrochloride. GSP is taken from the shells of shellfish and can also be made in a lab. The body uses GSP to make a variety of other chemicals for the construction of cartilage, ligaments, tendons, and a thick fluid that is found around the joints. Taking a supplement with GSP is intended to support cartilage and joint structure along with the fluid around the joints. Glucosamine hydrochloride (GHCl) has less evidence available behind it. It is also found in the shells of shellfish. Unlike Glucosamine sulfate potassium it lacks the sulfate component. This is the element your body needs to produce and maintain cartilage. Glucosamine HCl contains much less sodium. GHCl is often times found with chondroitin in hopes for better results. However, current findings in trials and research do not support this. For more of an in depth analysis of these two types, and why Flexcin contains GSP as opposed to GHCl please read our previous article here.

Glucosamine Sulfate Potassium & Flexcin

We include glucosamine sulfate potassium as a key part of the proprietary ingredients in Flexcin because we have researched and put together a high quality formula built to support everyday joint comfort. In addition to GSP, Flexcin uses a combination of all natural ingredients that support everyday joint comfort, including: CM8 (Cetyl-Myristoleate), Hydrolyzed Collagen Type II, MSM (Methylsulfonylmethane), Bromelain, and a blend of digestive enzymes. At Flexcin we stand behind our products and offer a 90 day supply of Flexcin, with no financial risk to you. If you’re not satisfied with the results you experience simply return your first order (up to three empty bottles) for a full refund of the purchase price, less shipping and handling.

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your healthcare provider before beginning any new supplement.